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methylprednisolone will decrease the level or effect of diazepam by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Use Warning/Keep track of.bosentan will reduce the level or impact of diazepam by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Monitor.Observe Closely (two)diazepam will raise the degree or outcome of mida